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KMID : 0624620160490090508
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BMB Reports
2016 Volume.49 No. 9 p.508 ~ p.513
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Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
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Choi Sik-Won
Lee Kwang-Sik
Lee Jin-Hwan
Kang Hyeon-Jung
Lee Mi-Ja
Kim Hyun-Young
Park Kie-In
Kim Sun-Lim
Shin Hye-Kyoung
Seo Woo-Duck
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Abstract
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Hypoxia-inducible factor (HIF)-1α is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1α regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1α inhibitor that inhibits the Akt signaling pathway. DAA dose-dependently inhibited hypoxia-induced HIF-1α and downregulated Akt signaling without affecting the stability of HIF-1α protein. Furthermore, DAA prevented hypoxia-mediated angiogenesis based on in vitro tube formation and in vivo chorioallantoic membrane (CAM) assays. Therefore, DAA might be useful for treatment of hypoxia-related tumorigenesis, including angiogenesis.
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KEYWORD
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Akt-HIF-1α signaling, Angiogenesis, Diacetyl atractylodiol, HIF-1α, Hypoxia
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